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Benefit Ledger · provisional · Biology

Chai-1 offers an open model for biomolecular complex prediction

Chai Discovery released Chai-1 in September–October 2024 as an open multi-modal structure model reporting PoseBusters and CASP15 scores near AlphaFold 3, with a web server usable for commercial drug discovery.

10 Oct 2024Tier 2 NotableMethodology 0.1

Current score

+0.28

3 base · Notable (tier 2 of 5, 3 pts)
× 0.9000 attribution · Primary causal contribution
× 0.3500 evidence · Technical disclosure or preprint
× 0.6000 realization · Experimentally validated
× 0.5000 durability
Event-level product before credit split: 0.28

Notable open AF3-class tool (tier 2). High attribution. Evidence is a technical report (0.35). Realization includes open weights and commercial web use. Durability medium as Boltz and AF3 successors compete.

What happened

The bioRxiv technical report described single-sequence and MSA modes and optional experimental restraints. Weights were released under a permissive license and a free web interface. Benchmarks are author-reported; there is no Nature/Science paper yet. Independent users have adopted the tool, but head-to-head audits vary by target class.

Model attribution

+0.28

Chai

Open structure-prediction model and server.

The released model is the product.

Attribution 0.9000 · Credit share 100% · Chai Discovery

Claims

  • Chai-1 was released with weights and reported AF3-comparable scores on selected public benchmarks.

    outcome · supported

Sources

primary sources

Secondary domains: Medicine & Health

Revision history

  • 13 Sep 2026 · 0.00 → 0.28

    Initial adjudicated seed score under methodology 0.1.