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Benefit Ledger · provisional · Biology

Evo 2 extends genomic language modeling across domains of life

Arc Institute released Evo 2 on 19 February 2025 as a larger DNA foundation model trained across eukaryotic and prokaryotic genomes, with public weights and reports of improved variant-effect and sequence-generation behavior versus Evo 1.

19 Feb 2025Tier 2 NotableMethodology 0.1

Current score

+0.24

3 base · Notable (tier 2 of 5, 3 pts)
× 0.8500 attribution · Primary causal contribution
× 0.3500 evidence · Technical disclosure or preprint
× 0.4500 realization · Experimentally validated
× 0.6000 durability
Event-level product before credit split: 0.24

Notable open genomic foundation model (tier 2). High attribution. Developer/preprint evidence. Realization is a research model. Provisional pending broader peer-reviewed wet-lab claims.

What happened

The announcement and accompanying paper described scaling to tens of billions of parameters and much longer genomic context, with experimental collaborators testing designed sequences. Independent clinical utility is not established. Treat as a methods and resource release.

Model attribution

+0.24

Evo

Scaled genomic foundation model released with weights.

The released model is the contribution.

Attribution 0.8500 · Credit share 100% · Arc Institute

Claims

  • Evo 2 was publicly released as a cross-domain DNA foundation model with open weights.

    outcome · supported

Sources

primary sources

Secondary domains: Medicine & Health

Revision history

  • 13 Sep 2026 · 0.00 → 0.24

    Initial adjudicated seed score under methodology 0.1.

Evo 2 extends genomic language modeling across domains of life · NetGoodIndex